反应详情

Methyl 2-[(2,6-dichlorobenzoyl)amino]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 35 (0.2 g) is solubilized in CH3CN/H2O/NaOH 0.1N (4 ml/0.22 ml/3.65 ml). After 1 night at room temperature, 10% KHSO4 (9 ml) is added and CH3CN is evaporated. The resulting aqueous phase is extracted two times with AcOEt (2×12 ml). The organic phase is washed with brine, dried over MgSO4 and evaporated under vacuum. The residue is purified by silica gel chromatography using CH2Cl2/CH3OH/NH4OH cc (90/10/1) as eluent.

1. waitAfter 1 night at room temperature
2. customCH3CN is evaporated
3. extractionThe resulting aqueous phase is extracted two times with AcOEt (2×12 ml)
4. washThe organic phase is washed with brine
5. dry with materialdried over MgSO4
6. customevaporated under vacuum
7. customThe residue is purified by silica gel chromatography