反应详情

To methyl 2-[(2,6-dichlorobenzyl)amino]-3-(4-nitrophenyl)propanoate 7a (8.2 g) solubilized in CH3COOH in an ultrasonic bath is added PtO2 hydrate (typical Pt content 79-84%) (0.02 g). A H2 pressure of 15 psi is then applied at RT and consumed after 5 min. An other H2 pressure of 10 psis is then applied at RT and consumed after 5-10 min. A H2 pressure of 10 psis is again applied at RT and a stabilization is observed after 5 min. The catalyst is filtered over celite under nitrogen and washed with CH3COOH. The solvent is evaporated. AcOEt (200 ml) is added to the residue and this organic phase is washed three times with saturated NaHCO3 (200 ml), dried over MgSO4 and evaporated. The residue is purified by silica gel chromatography using CH2Cl2/CH3OH/NH4OH cc (99.75/0.25/0.025) as eluent.

1. customis then applied at RT
2. customconsumed after 5 min
3. customis then applied at RT
4. customconsumed after 5-10 min
5. customis again applied at RT
6. filtrationThe catalyst is filtered over celite under nitrogen
7. washwashed with CH3COOH
8. customThe solvent is evaporated
9. additionAcOEt (200 ml) is added to the residue
10. washthis organic phase is washed three times with saturated NaHCO3 (200 ml)
11. dry with materialdried over MgSO4
12. customevaporated
13. customThe residue is purified by silica gel chromatography