HCID 11181389, compound → HCID 11467974, compound

HRID 1869788Notes

Reaction equation

HRID 1869788 reaction equation
C(NC(CC1C=C2C(=CC=1)NC(C1C(Cl)=CC=CC=1Cl)CC2SC1C=CC=CC=1)C(OC)=O)(=[O:8])C1C=CC=CC=1.[Cl:41][C:42]1[CH:80]=[CH:79][CH:78]=[C:77]([Cl:81])[C:43]=1[CH2:44][NH:45][CH:46]([CH2:51][C:52]1[CH:53]=[C:54]2[C:59](=[CH:60][CH:61]=1)[NH:58][CH:57]([C:62]1[C:67]([Cl:68])=[CH:66][CH:65]=[CH:64][C:63]=1[Cl:69])[CH2:56][CH:55]2[S:70][C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1)[C:47]([O:49][CH3:50])=[O:48].ClC1C=CC=C(Cl)C=1C(NC(CC1C=C2C(=CC=1)NC(C1C(OC)=CC=CC=1OC)CC2SC1C=CC=CC=1)C(OC)=O)=O.ClC1C=CC=C(Cl)C=1C(NC(CC1C=C2C(=CC=1)NC(C1SC=CN=1)CC2SC1C=CC=CC=1)C(OC)=O)=O.ClC1C=CC=C(Cl)C=1C(NC(CC1C=C2C(=CC=1)NC(C1C(Cl)=CN=CC=1Cl)CC2SC1C=CC=CC=1)C(OC)=O)=O.ClC1C=CC=C(Cl)C=1C(NC(CC1C=C2C(=CC=1)NC(C1C=CN=CC=1)CC2SC1C=CC=CC=1)C(OC)=O)=O>>[Cl:81][C:77]1[CH:78]=[CH:79][CH:80]=[C:42]([Cl:41])[C:43]=1[C:44]([NH:45][CH:46]([CH2:51][C:52]1[CH:53]=[C:54]2[C:59](=[CH:60][CH:61]=1)[NH:58][CH:57]([C:62]1[C:63]([Cl:69])=[CH:64][CH:65]=[CH:66][C:67]=1[Cl:68])[CH2:56][CH:55]2[S:70][C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1)[C:47]([O:49][CH3:50])=[O:48])=[O:8]

Participants

7

Reactant 6

HCID 11181389HCID 11181389, compoundHCID 11250808HCID 11250808, compoundHCID 11261901HCID 11261901, compoundHCID 11296686HCID 11296686, compoundHCID 11387747HCID 11387747, compoundHCID 11421971HCID 11421971, compound

Product 1

HCID 11467974HCID 11467974, compound

Procedure

Methyl 2-(benzoylamino)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9a, methyl 2-[(2,6-dichlorobenzyl)amino]-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9b (MS (MH+): 645/647/649), methyl 2-[(2,6-dichlorobenzoyl)amino]-3-[2-(2,6-dimethoxyphenyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9c (MS (MH+): 651/653/655), methyl 2-[(2,6-dichlorobenzoyl)amino]-3-[4-(phenylsulfanyl)-2-(1,3-thiazol-2-yl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9d (MS (MH+): 596/598/600), methyl 2-[(2,6-dichlorobenzoyl)amino]-3-[2-(3,5-dichloro-4-pyridinyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9e (MS (MH+): 658/660/662) and methyl 2-[(2,6-dichlorobenzoyl)amino]-3-[4-(phenylsulfanyl)-2-(4-pyridinyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 9f (MS (MH+): 590/592/594) can be synthesized according to the same method.

Sources & evidence

ORD record
ord-088f347ff12947e3974b78ed8d3e16fd
Source dataset
uspto-grants-2009_12
Patent number
US07638630B2

Reaction notes

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