反应详情

To 0.62 g of methyl 2-amino-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 33 in CH2Cl2 (10 ml) are added 0.343 g of 2,6-dichlorophenyl isocyanate. The solution is stirred at RT and reduced to the half by evaporation. The solid residue is filtered and washed with CH2Cl2 and hexane to give a white powder that is recrystallised in hot CH3CN. The compound is purified over silica gel using CH2Cl2/CH3OH 99.5/0.5 as eluent. The obtained white powder is once more washed with CH3CN to give methyl 2-{[(2,6-dichloroanilino)carbonyl]amino}-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 52.

1. customreduced to the half by evaporation
2. filtrationThe solid residue is filtered
3. washwashed with CH2Cl2 and hexane
4. customto give a white powder that
5. customis recrystallised in hot CH3CN
6. customThe compound is purified over silica gel
7. washThe obtained white powder is once more washed with CH3CN