Dichloromethane → HCID 68592948, compound

Participants

Reaction Steps

To a solution of 2-[(tert-butoxycarbonyl)amino]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]-2-propenoate 22 (0.48 g) in CH2Cl2 (2 ml) are added at 0° C. two drops of anisole and 1.6 ml of trifluoroacetic acid. The solution is stirred for 2 h and a solution of NaHCO3 saturated is added to reach a basic pH. The aqueous phase is extracted with AcOEt (3×10 ml). The organic phases are washed with brine, dried over MgSO4 and concentrated. The residue is washed with methanol to give methyl 3-[2-(2,6-dichlorophenyl)-6-quinolinyl]-2-hydroxy-2-propenoate 23.

Provenance & Evidence