Sodium Hydroxide → HCID 57987630, compound

Participants

Reaction Steps

A solution of methyl 2-[(2,6-dichlorobenzyl)oxy]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 56 (0.123 g) and 1 N NaOH (0.236 ml) in a mixture of acetonitrile/water (3 ml/0.14 ml) is stirred for 3 h at room temperature. After addition of a 10% KHSO4 solution (3 ml), the mixture is concentrated. The aqueous phase is extracted with AcOEt (3×10 ml). The organic phases are washed with brine, dried over MgSO4 and evaporated under vacuum. The residue is washed with CH2Cl2 and 2-[(2,6-dichlorobenzyl)oxy]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoic acid 91 is obtained as a white powder.

Provenance & Evidence