HRID1869812

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@@H](Cc1ccc2c(c1)C(Sc1ccccc1)CC(c1c(Cl)cccc1Cl)N2)NC(=O)c1c(Cl)cccc1Cl

HCID11273829

未命名化合物

结构：O=C(N[C@H](Cc1ccc2nc(-c3c(Cl)cccc3Cl)ccc2c1)C(=O)O)c1c(Cl)cccc1Cl

HCID44429938

未命名化合物

PRODUCTS

生成物

HCID9958757

未命名化合物

PROCEDURE

实验过程

(2R)-2-[(2,6-dichlorobenzoyl)amino]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoic acid 40 can be synthesised according to the same procedure but starting from (D)-p-nitro-Phe-OMe, involving methyl (2R)-2-[(2,6-dichlorobenzoyl)amino]-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 24a (MS (MH+): 659/661) as intermediate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-51e25f7c5aef4a239083f814bcafa759
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07638630B2
来源说明: uspto-grants-2009_12

反应 SMILES

[Cl:1][C:2]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:3]=1[C:4]([NH:6][C@H:7]([CH2:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([C:22]1[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:29])[CH:16]=[CH:15]2)[C:8]([OH:10])=[O:9])=[O:5].ClC1C=CC=C(Cl)C=1C(N[C@H](CC1C=C2C(=CC=1)NC(C1C(Cl)=CC=CC=1Cl)CC2SC1C=CC=CC=1)C(OC)=O)=O>>[Cl:1][C:2]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:3]=1[C:4]([NH:6][C@@H:7]([CH2:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([C:22]1[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:29])[CH:16]=[CH:15]2)[C:8]([OH:10])=[O:9])=[O:5]