Hydrochloric Acid → HCID 68592174, compound

Participants

Reaction Steps

To a solution of 1,4-dioxane (1 ml) are added successively 6 N HCl (3 ml) and methyl 2-(acetylamino)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]propanoate 207 (0.135 g). The solution is stirred and heated at reflux for 4 hours, then cooled, and diethyl ether (5 ml) is added. The aqueous phase is extracted with diethyl ether (35 ml). The organic phase is concentrated under vacuum. The resulting residue is dried overnight under high pression to give 2-amino-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]propanoic acid hydrochloride 208.

Provenance & Evidence