反应详情

5-(4-Bromo-2-methoxy-phenyl)-2-methyl-pentan-2-ol (Intermediate 62, 7.3 g, 24.6 mmol) was treated with 85% sulfuric acid (25 mL) at ambient temperature. After 30 minutes, the reaction mixture was diluted with cold water and extracted with diethyl ether. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product (5.6 g, 83%).

1. extractionextracted with diethyl ether
2. washThe organic phase was washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated in vacuo