Methanol → HCID 10931849, compound

HRID 1870059Notes

Reaction equation

HRID 1870059 reaction equation
[CH3:1][C:2]([C:6]([OH:8])=[O:7])([CH2:4][OH:5])[NH2:3].O=S(Cl)Cl.[CH3:13]O>>[CH3:13][O:7][C:6](=[O:8])[C:2]([NH2:3])([CH3:1])[CH2:4][OH:5]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl Chloride2×HCID 94309alpha-Methyl-DL-serine

Product 1

HCID 10931849HCID 10931849, compound

Conditions

Temperature
0 °C

Procedure

A stirring solution of α-methyl-DL-Serine (1 g, 8.39 mmol) in MeOH (40 mL) in a flame dried round bottom flask under an inert atmosphere was cooled to 0° C. and SOCl2 (1.84 mL, 25.19 mmol) was slowly added. After addition of the SOCl2 was complete, the reaction mixture was stirred 12 hours at room temperature and then concentrated in vacuo to a white solid that was used directly in the next reaction.

Workup

  1. concentrationconcentrated in vacuo to a white solid that
  2. customwas used directly in the next reaction

Sources & evidence

ORD record
ord-42eb7d27a9fa4428af03fb9046906921
Source dataset
uspto-grants-2009_12
Patent number
US07638637B2

Reaction notes

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