Bromide ion → HCID 54263737, compound

Participants

Reaction Steps

36 g of p-methoxybenzoyl chloride are reacted with 1 Eq of 6-methoxy-2-bromonaphthalene magnesium in a solution in THF (solution prepared by reacting the bromide with 1.5 Eq of magnesium, followed by filtration) at 0° C. for 2 h. The medium is then poured into a mixture of 300 g of ice and 50 mL of concentrated HCl. The precipitate formed is recovered and washed with water (3×500 mL). After drying, 61 g of 2-(6-methoxynaphth-2-yl)-(4-methoxyphenyl) ketone are obtained.

Provenance & Evidence