反应详情

A solution of 1 g (2.6 mmol) of 5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)-2,4-dichlorobenzoyl chloride and 0.5 g (3.8 mmol) of 2-(2-pyrrolidon-1-yl)ethanol in 20 ml of pyridine was stirred for approximately 15 hours, whereupon the reaction mixture was concentrated. The residue was treated with 10 ml of water and 20 ml of ethyl acetate. The organic phase was then separated off, dried over magnesium sulfate and concentrated. The crude product was purified by column chromatography on silica gel (eluent: initially hexane/ethyl acetate=1:1, then ethyl acetate). Yield: 0.8 g.

1. concentrationwas concentrated
2. additionThe residue was treated with 10 ml of water and 20 ml of ethyl acetate
3. customThe organic phase was then separated off
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe crude product was purified by column chromatography on silica gel (eluent