Imidazole → HCID 18695446, compound

HRID 1870204Notes

Reaction equation

HRID 1870204 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([F:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1.N1C=CC=CC=1>CS(C)=O>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:10]([F:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2]

Participants

5

Reactant 3

HCID 795ImidazoleHCID 1049PyridineHCID 18695404HCID 18695404, compound

Product 1

HCID 18695446HCID 18695446, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

By using 0.59 g of N-(4,5-difluoro-2-nitrophenyl)glycine ethyl ester, 155 mg of imidazole, 1.80 g of pyridine and 10 ml of DMSO, 0.41 g (59%) of N-[4-fluoro-5-(1H-imidazol-1-yl)-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-bc592c49c8c143beaea244092e4c55c3
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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