Imidazole → HCID 18695460, compound

HRID 1870206Notes

Reaction equation

HRID 1870206 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([Cl:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:10]([Cl:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695394HCID 18695394, compound

Product 1

HCID 18695460HCID 18695460, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.16-1.47 (3H, m), 4.04 (2H, d, J=5.3 Hz) 4.16-4.45 (2H, m), 6.47 (1H, d, J=11.1 Hz), 8.25-8.67 (2H, m). 2) By using 0.66 g of N-(4-chloro-5-fluoro-2-nitrophenyl)glycine ethyl ester, 162 mg of imidazole and 4 ml of pyridine, 0.44 g (57%) of N-[4-chloro-5-(1H-imidazol-1-yl)-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-94d8c342eb19487b97329495a7689a7a
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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