HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-(4-benzyloxy-5-fluoro-2-nitrophenyl)glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Reactant | 1,5-Difluoro-2-nitro-4-(phenylmethoxy)benzene | HCID 18695436 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-benzyloxy-5-fluoro-2-nitrophenyl)glycine ethyl ester | HCID 18695453 | 8% |
Reaction Steps
By using 4.41 g of benzyl 2,4-difluoro-5-nitrophenyl ether, 5.05 g of triethylamine, 30 ml of DMF, 30 ml of THF and 2.32 g of glycine ethyl ester hydrochloride, 454 mg (8%) of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)glycine ethyl ester was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06096743 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-036383ab067c48c3bf432425603216b2 |
| Source note | uspto-grants-2000_08 |