Ethyl bromoacetate → HCID 54140021, compound

Participants

Reaction Steps

In 20 ml of DMF, 500 mg of 7-fluoro-1-hydroxy-6-nitro-2,3(1H,4H)-quinoxalinedione was dissolved. To the aresulting solution, 83 mg of sodium hydride was added, followed by stirring for 10 minutes. To the reaction -z mixture, 218 ml of ethyl bromoacetate was added, followed by reaction for 2 days. The reaction mixture was poured into a saturated aqueous solution of ammonium chloride, followed by extraction with chloroform three times. The organic layer was concentrated, followed by recrystallization from 2-propanol to give 481 mg of ethyl 2-[(2,3-dioxo-7-fluoro-6-nitro-1,2,3,4-tetrahydroquinoxalinyl)oxy]acetate.

Provenance & Evidence