Calciumoxide → HCID 11447366, compound

Participants

Reaction Steps

A mixture of (±)-cis-1-(phenylmethyl)-3-hydroxy-4-piperidinemethanol (0.11 mol) and calcium oxide (5 g) in tetrahydrofuran (250 ml) was hydrogenated with copper chromite (CuO.Cr2O3) (4 g) as a catalyst at 120° C. The catalyst was filtered off and the filtrate was evaporated. The residue was purified by column chromatography (CH2Cl2 /CH3OH/CH3OH(NH3): 93/5/2). The fractions were evaporated, yielding 8.5 g of (±)-cis-1-(phenylmethyl)-3-hydroxy-4-piperidinemethanol and 6.32 g of (±)-trans-1-(phenylmethyl)-3-hydroxy-4-piperidinemethanol.

Provenance & Evidence