Piconol → HCID 53791088, compound

Participants

Reaction Steps

A solution of 2-chloromethyl-1-isocyanato-3-methylbenzene (2.5 g) and 2-hydroxymethylpyridine (1.5 g) in dichloromethane (25 ml) is stirred at RT for 16 h. By concentration on a rotary evaporator (bath temperature 22° C.) and subsequent chromatography on silica gel (eluent: dichloromethane/methanol 13:1), a solution of the title compound is obtained which is concentrated (not crystallization, but decomposition) on a rotary evaporator. (bath temperature 22° C.). The crude product of the title compound obtained is immediately reacted further.

Provenance & Evidence