Hydrochloric Acid → HCID 11811713, compound

Participants

Reaction Conditions

Reaction Steps

5-Methoxycarbonylmethyl-1-[4-(1-pyrrolidinyl)-2-chlorobenzoyl]-2,3,4,5-tetrahydro-1H-benzazepine (183 g) is suspended in methanol (2 liters), and thereto is added a 5N sodium hydroxide (171 ml), and the mixture is stirred at 60° C. for four hours. To the mixture is added a 5N sodium hydroxide (60 ml), and the mixture is stirred at 70° C. for one hour. The mixture is acidified with hydrochloric acid, and concentrated under reduced pressure to remove the methanol. The crystals are collected by filtration, washed with water, and dried to give 5-carboxymethyl-1-[4-(1-pyrrolidinyl)-2-chlorobenzoyl]-2,3,4,5-tetrahydro-1H-benzazepine (142 g).

Provenance & Evidence