Water → HCID 69835226, compound

Participants

Reaction Steps

To a solution of 5-carboxymethylidene-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-benzazepine (3.0 g) and isopropylamine (2.5 g) in dimethylformamide (30 ml) is added diethyl cyanophosphate (2.1 g), and the mixture is stirred at room temperature for 30 minutes. To the mixture is added water, and the mixture is extracted with ethyl acetate. The extract is washed with water, dried, concentrated, and the precipitated crystals are recrystallized from chloroform--diisopropyl ether to give 5-isopropylaminomethylidene-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-benzazepine (trans-compound) (3.2 g).

Provenance & Evidence