Ethyl Acetate → HCID 15895925, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-methoxycarbonylmethyl-1-(4-amino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (50 g), n-iodopropane (130 ml) and sodium carbonate (185 g) in dimethylformamide (1.0 liter) is stirred overnight at 60° C. To the mixture is added ethyl acetate, and the mixture is washed with water, dried, concentrated, and purified by silica gel column chromatography (solvent; dichloromethane:methanol=50:1) to give 5-methoxycarbonylmethyl-1-(4-n-propylamino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (30 g) as a white powder.

Provenance & Evidence