Isopropylamine → HCID 11091484, compound

Participants

Reaction Steps

To a solution of the above product, 5-carboxymethyl-1-(4-n-propylamino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (800 mg) and isopropylamine (1.0 ml) in dimethylformamide (20 ml) is added dropwise diethyl cyanophosphate (391 mg) at room temperature. The mixture is stirred overnight, and thereto is added ethyl acetate. The mixture is washed with water, dried, concentrated, and purified by silica gel column chromatography (solvent; dichloromethane:methanol=50:1), and further crystallized from diethyl ether to give 5-isopropylaminocarbonylmethyl-1-(4-n-propylamino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (840 mg).

Provenance & Evidence