Sodium Hydroxide → HCID 18696163, compound

HRID 1870277Notes

Reaction equation

HRID 1870277 reaction equation
[ClH:1].Cl.[NH2:3][CH2:4][CH2:5][O:6][C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]=2[O:9][N:8]=1.[OH-].[Na+]>O>[ClH:1].[NH2:3][CH2:4][CH2:5][O:6][C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]=2[O:9][N:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18696042HCID 18696042, compound

Product 1

HCID 18696163HCID 18696163, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solvent of 3-(2-aminoethoxy)pyrido[3,2-d]isoxazole dihydrochloride in water (10 ml) was added aqueous 1N sodium hydroxide solution (16 ml) with stirring under ice cooling, and the mixture was then stirred at the same temperature for 5 minutes. The reaction mixture was evaporated under reduced pressure and the title compound (3.2 g, 94%) was obtained as colorless crystals by recrystallizing from methanol-water mixture (1:1).

Workup

  1. stirringthe mixture was then stirred at the same temperature for 5 minutes
  2. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0fa439767bbd4bcbb4cfb9458c1df3c6
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

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