HCID 15453957, compound → HCID 18696240, compound

HRID 1870280Notes

Reaction equation

HRID 1870280 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[C:17]([CH3:22])=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[C:17]([CH3:22])=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

3

Reactant 2

HCID 15453957HCID 15453957, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18696240HCID 18696240, compoundYield 98%

Procedure

3-(2-(N-t-butoxycarbonylamino)ethoxy)-5-fluoro-4-methyl-1,2-benzisoxazole (0.15 g) was dissolved in 4N hydrochloric acid/dioxane solution (1.4 ml) and stirred for 15 minutes. The reaction mixture was evaporated under reduced pressure and the precipitated crystals were filtered. The title compound (0.13 g, 98% yield) was obtained as a colorless powder by washing the crystals with ethyl acetate (3 ml).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. filtrationthe precipitated crystals were filtered

Sources & evidence

ORD record
ord-44f249824f1d4d8f96e30a689a4a371a
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

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