HCID 15453959, compound → HCID 15453964, compound

HRID 1870284Notes

Reaction equation

HRID 1870284 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[C:17]([C:22]([OH:24])=[O:23])=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N+](=[CH2:27])=[N-].C(OCC)C>C(OCC)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[C:17]([C:22]([O:24][CH3:27])=[O:23])=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 15453959HCID 15453959, compoundHCID 21186548Diazomethane diethylether

Product 1

HCID 15453964HCID 15453964, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 3-(2-(N-t-butoxycarbonylamino)ethoxy)-4-carboxy-5-fluoro-1,2-benzisoxazole (0.31 g) in diethylether (20 ml) was added diazomethane/diethylether solution at 5° C. until the reaction mixture became yellow, and the mixture was then stirred for 15 minutes. The reaction mixture was evaporated under reduced pressure to give the title compound (0.32 g, 100% yield) as an oil.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9415dee9d3454af6ab97cc4296ff1550
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

Loading…