HCID 15453974, compound → HCID 18696217, compound

HRID 1870292Notes

Reaction equation

HRID 1870292 reaction equation
C(OC([NH:8][CH2:9][CH2:10][S:11][C:12]1[C:16]2[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.[ClH:22].O1CCOCC1>O1CCOCC1>[ClH:22].[NH2:8][CH2:9][CH2:10][S:11][C:12]1[C:16]2[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

4

Reactant 2

HCID 15453974HCID 15453974, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18696217HCID 18696217, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
5 °C

Procedure

To a solution of 3-(2-(N-t-butoxycarbonylamino)ethylthio)-5-fluoro-1,2-benzisoxazole (0.20 g) in dioxane (2 ml) was added 4 N-hydrochloric acid/dioxane solution (0.8 ml) with stirring at 5° C., and the mixture was then stirred at room temperature for 30 minutes. After completion of the reaction, the solvent was evaporated under reduced pressure and the residue was recrystallized from ethanol and ethyl acetate, to give the title compound (0.14 g) as a colorless needle.

Workup

  1. stirringthe mixture was then stirred at room temperature for 30 minutes
  2. customAfter completion of the reaction
  3. customthe solvent was evaporated under reduced pressure
  4. customthe residue was recrystallized from ethanol and ethyl acetate

Sources & evidence

ORD record
ord-5bb6cce70c8744a0955e598447e5aa4f
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

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