Potassium Hydroxide → HCID 178489212, compound

HRID 1870298Notes

Reaction equation

HRID 1870298 reaction equation
F[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:3]=1[C:4]([NH:6][OH:7])=[O:5].[OH-].[K+]>C(O)CCC>[OH:5][C:4]1[C:3]2[C:8]([O:12][CH3:13])=[CH:9][CH:10]=[CH:11][C:2]=2[O:7][N:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18696145HCID 18696145, compound

Product 1

HCID 178489212HCID 178489212, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

2-fluoro-6-methoxybenzhydroxamic acid (2.55 g) and potassium hydroxide (4.50 g) were dissolved in butanol (25 ml) and refluxed for 4 hours. After the completion of the reaction, the reaction mixture was adjusted to acidic, extracted with ethyl acetate and the extract was washed with water and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure and the residue was recrystallized from isopropylether, to give the title compound (2.05 g, 90%).

Workup

  1. temperaturerefluxed for 4 hours
  2. customAfter the completion of the reaction
  3. extractionextracted with ethyl acetate
  4. washthe extract was washed with water
  5. dry with materialdried over anhydrous sodium sulphate
  6. customThe solvent was evaporated under reduced pressure
  7. customthe residue was recrystallized from isopropylether

Sources & evidence

ORD record
ord-e35fde9552374a469e624fad17373e2b
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

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