Chloroacetic Acid → N-(3,4-dichlorophenyl)glycine

HRID 1870308Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].Cl[CH2:11][C:12]([OH:14])=[O:13]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:11][C:12]([OH:14])=[O:13])[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

Reactant 2

HCID 300Chloroacetic Acid

HCID 72573,4-Dichloroaniline

Product 1

HCID 351250N-(3,4-dichlorophenyl)glycine

Procedure

Using the procedure set forth in U.S. Pat. No. 3,598,859, N-(3,4-dichlorophenyl)glycine was prepared using 3,4-dichloroaniline (Aldrich) and 2-chloroacetic acid (Aldrich).

Sources & evidence

ORD record: ord-52b8bd3f554842b6bd9f7d32d098aca7
Source dataset: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06096782

Reaction notes

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