2-(3,4-Dichloro-phenylamino)-propionic Acid → HCID 53891092, compound

HRID 1870327Notes

Reaction equation

HRID 1870327 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:11])[C@H:5]([CH2:7][CH2:8][S:9][CH3:10])[NH2:6].[Cl:12][C:13]1[CH:14]=[C:15]([NH:20][CH:21]([C:23](O)=[O:24])[CH3:22])[CH:16]=[CH:17][C:18]=1[Cl:19]>>[CH3:2][O:3][C:4](=[O:11])[C@H:5]([CH2:7][CH2:8][S:9][CH3:10])[NH:6][C:23](=[O:24])[CH:21]([CH3:22])[NH:20][C:15]1[CH:16]=[CH:17][C:18]([Cl:19])=[C:13]([Cl:12])[CH:14]=1

Participants

3

Reactant 2

HCID 69164262-(3,4-Dichloro-phenylamino)-propionic AcidHCID 11435579L-Methionine, methyl ester, hydrochloride

Product 1

HCID 53891092HCID 53891092, compound

Procedure

Following General Procedure D and using L-methionine methyl ester hydrochloride (Sigma) and N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above), the title compound was prepared as a mixture of diastereomers. The reaction was monitored by tlc (Rf=0.35 in 43% EtOAc/hexanes) and purification of this compound was by flash chromatography with 43% EtOAc/hexanes.

Workup

  1. customThe reaction was monitored by tlc (Rf=0.35 in 43% EtOAc/hexanes) and purification of this compound

Sources & evidence

ORD record
ord-8483eecfe10d4173a8a76bcd8a505b29
Source dataset
uspto-grants-2000_08
Patent number
US06096782

Reaction notes

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