methyl (2S)-2-aminohexanoate hydrochloride → HCID 53843208, compound

HRID 1870332Notes

Reaction equation

HRID 1870332 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:11])[C@H:5]([CH2:7][CH2:8][CH2:9][CH3:10])[NH2:6].[F:12][C:13]1[CH:14]=[C:15]([NH:20][CH:21]([C:23](O)=[O:24])[CH3:22])[CH:16]=[C:17]([F:19])[CH:18]=1>>[CH3:2][O:3][C:4](=[O:11])[C@@H:5]([NH:6][C:23](=[O:24])[CH:21]([CH3:22])[NH:20][C:15]1[CH:16]=[C:17]([F:19])[CH:18]=[C:13]([F:12])[CH:14]=1)[CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 14039065methyl (2S)-2-aminohexanoate hydrochlorideHCID 15484845HCID 15484845, compound

Product 1

HCID 53843208HCID 53843208, compound

Procedure

Following General Procedure E and using L-norleucine methyl ester hydrochloride (Sigma) and N-(3,5-difluorophenyl)-D,L-alanine, the title compound was prepared as a solid (mp=93-95° C.). The reaction was monitored by tlc (Rf=0.6 in 3% methanol/methylene chloride) and purification of this compound was by flash chromatography with 3% methanol/methylene chloride.

Workup

  1. customThe reaction was monitored by tlc (Rf=0.6 in 3% methanol/methylene chloride) and purification of this compound

Sources & evidence

ORD record
ord-1561f6d7493d4ea293569ce7df7d536a
Source dataset
uspto-grants-2000_08
Patent number
US06096782

Reaction notes

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