2-Amino-2-phenylethan-1-ol → N-[-N-(3,5-dichlorophenyl)-D,L-alanyl]-(S)-2-amino-2-phenylethanol

HRID 1870334Notes

Reaction equation

HRID 1870334 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH:10]([C:12]([OH:14])=O)[CH3:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:15]1([C@@H:21]([CH2:23][OH:24])[NH2:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:8][C:6]1[CH:5]=[C:4]([NH:9][CH:10]([C:12]([NH:22][C@@H:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:23][OH:24])=[O:14])[CH3:11])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 1347972-Amino-2-phenylethan-1-olHCID 15484844N-(3,5-dichlorophenyl)-D,L-alanine

Product 1

HCID 131721935N-[-N-(3,5-dichlorophenyl)-D,L-alanyl]-(S)-2-amino-2-phenylethanol

Procedure

Following General Procedure E and using N-(3,5-dichlorophenyl)-D,L-alanine (from Example B above) and (S)-(+)-2-phenylglycinol (Aldrich), the title compound could be prepared.

Sources & evidence

ORD record
ord-22f050b09e1340b0991364bede4e5a3f
Source dataset
uspto-grants-2000_08
Patent number
US06096782

Reaction notes

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