Water → HCID 69116751, compound

Participants

Reaction Conditions

Reaction Steps

Into a suspension of NaN3 (260 mg, 4 mmol) in 4 ml dry DMF was added 150 mg tamoxifen tosylate (TX-OTs) (0.25 mmol). The reaction mixture was stirred at 90° C. overnight. To terminate the reaction, the vxn mixture was poured into cold water and extracted with ethyl ether (3×50 ml). The organic layers were combined and washed with H2O (2×50 ml). The ether layer was then dried over magnesium sulfate and evaporated. Further purification by flash chromatography (ether/petroleum ether/triethyl amine=5/5/1) yielded pure TX-N3. Yield 50% IR: 2150 cm-1 (Azide).

Provenance & Evidence