Carbon tetrabromide → HCID 18696595, compound

Participants

Reaction Steps

To a suspension of the title compound of Step E (2.6 g) in methylene chloride (20 mL) under N2 at room temperature was added sequentially triphenylphosphine (3.44 g) and carbon tetrabromide (5.58 g). The resulting orange solution was allowed to stir for 1 h at room temperature and was then concentrated under reduced pressure to give an orange oil. The residue was purified by flash chromatography (1:1 ethyl acetate:hexane as eluent) to afford 2.3 g of the title compound of Step F, a compound of the invention, as a white solid. 1H NMR (CDCl3): δ 7.34 (d,1H), 6.92 (d,1H), 4.65 (s,2H), 3.98 (s,3H), 3.45 (s,3H).

Provenance & Evidence