Carbon tetrabromide → HCID 18696590, compound

Participants

Reaction Steps

To a solution of the title compound of Step F (3.6 g), and triphenylphosphine (5.1 g) in methylene chloride (40 mL) under N2 at 0° C. was added carbon tetrabromide (8.0 g). The resulting orange solution was allowed to stir overnight at room temperature and then was concentrated under reduced pressure to give a brown oil. The residue was purified by flash chromatography (1:2 ethyl acetate:hexane as eluent) to afford 3.6 g (78%) of the title compound of Step G, a compound of the invention, as a white solid melting at 147-149° C.

Provenance & Evidence