HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-(3-Amino-4-chlorophenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Benzene, 1,3-dichloro-2,4-dinitro- | HCID 3014625 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(3-Amino-4-chlorophenyl)acetamide | HCID 103996 | 85% |
Reaction Steps
A hydrogenation reactor is charged with 15 parts of sodium acetate, 60 parts of NaHCO3, 1320 parts of MeOH and 1015 parts of 1-chloro-2,4-dinitrochlorobenzene under nitrogen at 50° C. and then 11 parts of 1% Pt/C, 0.15 parts of NH4VO3 and 66 parts of water are added.The hydrogenation is carried out at 60° C. and 18 bar. The product is isolated as 3-amino-4-chloroacetanilide (785 parts, 85% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06096924 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-a6c2fb3fabda4893b012889bd6601f8d |
| Source note | uspto-grants-2000_08 |