Cesium carbonate → HCID 86755581, compound

Participants

Reaction Steps

From 4-(3-(2,2,2-trifluoroethyl)-2-oxo-1-benzimidazolinyl)piperidine [prepared by a modification of Step 2 of Example 1 wherein cesium carbonate replaced the sodium hydride and the reaction was heated at 50° C. for 20 hours] and 1,1-dioxido-2-(4-bromobutyl)-5-chloro-1,2-benzisothiazol-3(2H)-one using the procedures described in Example 1 there was obtained a white solid upon formation of the HCl salt (from methanol and diethyl ether), melting point 237-239° C. Analysis calculated for C25H26ClF3N4O4S.HCl.0.4 H2O: C,48.85; H,4.56; N,9.12; found: C,48.83 ; H,4.53 ; N,9.04. The NMR was consistent with the structure.

Provenance & Evidence