HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxide → 1,1-Dioxido-2-(4-(4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-5-chloro-1,2-benzisothiazol-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxide | HCID 13365980 | — |
| Reactant | 4-(5-Fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidine | HCID 18696000 | — |
| Product | 1,1-Dioxido-2-(4-(4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-5-chloro-1,2-benzisothiazol-3(2H)-one | HCID 10075817 | — |
Reaction Steps
Starting with 4-(5-fluoro-3-ethyl-2-oxo-1-benzimidazolinyl)piperidine and 1,1-dioxido-2-(4-bromobutyl)-5-chloro-1,2-benzisothiazol-3(2H)-one and following the procedure of Example 1, the title compound was obtained as the HCl salt, melting point 266-268° C. The NMR was consistent with the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06096763 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-c9ea745b10884c399ccbeb9639472f5e |
| Source note | uspto-grants-2000_08 |