Potassium Iodide → HCID 86754463, compound

HRID 1870609Notes

Reaction equation

HRID 1870609 reaction equation
[C:1]([C@H:3]1[CH2:8][C@H:7]([N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]([CH2:18][CH2:19][CH3:20])[C:10]2=[O:21])[CH2:6][CH2:5][NH:4]1)#[N:2].[O:22]=[S:23]1(=[O:39])[C:27]2[CH:28]=[CH:29][C:30]([Cl:32])=[CH:31][C:26]=2[C:25](=[O:33])[N:24]1[CH2:34][CH2:35][CH2:36][CH2:37]Br.[I-].[K+]>>[O:39]=[S:23]1(=[O:22])[C:27]2[CH:28]=[CH:29][C:30]([Cl:32])=[CH:31][C:26]=2[C:25](=[O:33])[N:24]1[CH2:34][CH2:35][CH2:36][CH2:37][N:4]1[CH2:5][CH2:6][C@@H:7]([N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]([CH2:18][CH2:19][CH3:20])[C:10]2=[O:21])[CH2:8][C@@H:3]1[C:1]#[N:2]

Participants

4

Reactant 3

HCID 4875Potassium IodideHCID 133659801,2-Benzisothiazol-3(2H)-one, 2-(4-bromobutyl)-5-chloro-, 1,1-dioxideHCID 86754464HCID 86754464, compound

Product 1

HCID 86754463HCID 86754463, compound

Conditions

Temperature
80 °C

Procedure

From (±) cis/trans-2-cyano-4-(3-n-propyl-2-oxo-1-benzimidazolinyl)-piperidine and 1,1-dioxido-2-(4-bromobutyl)-5-chloro-1,2-benzisothiazol-3(2H)-one using a modification of the procedure described in Example 1, Step 4, wherein one equivalent of potassium iodide was added and the reaction was warmed at 80° C. for 24 hours, there was obtained a white solid after chromatographic purification, melting point 159-160° C. The NMR was consistent with structure.

Workup

  1. additionwas added
  2. customthere was obtained a white solid
  3. customafter chromatographic purification, melting point 159-160° C

Sources & evidence

ORD record
ord-0046e9150ff84104a283e37cc61212a9
Source dataset
uspto-grants-2000_08
Patent number
US06096763

Reaction notes

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