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Hydroxide → 5-Fluoro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxide | HCID 961 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 13792186 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 5-Fluoro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | HCID 13792104 | — |
反応手順
A suspension of 1-ethoxycarbonyl-4-(5-fluoro-2-oxo-1-benzimidazolinyl)piperidine (5.22 g, 17 mmol.) in 2 N NaOH (55 mL) was refluxed for twelve hours. The clear amber solution was cooled to room temp. and solid NH4Cl (5.9 g, 110 mmol.) was added to neutralized the hydroxide. After addition of aq. Na2CO3 and 5 N NaOH (2 mL), the product was extracted into chloroform. The extract was dried (Na2SO4) and filtered through a pad of charcoal and then evaporated to give 4-(5-fluoro-2-oxo-1-benzimidazolinyl)piperidine as a pale yellow viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06096763 |
| 出典データセット | uspto-grants-2000_08 |
| ORD ID | ord-d45bd9a535514a40a31fedc668b03c53 |
| 出典メモ | uspto-grants-2000_08 |