2-Dimethylaminopyridine → HCID 136200006, compound

Participants

Reaction Steps

To a solution of 9.3 g of the 5-(6-chloro-2-ethyl-2,4,7-trimethylindan-5-yl)-cyclohexane-1,3-dione in 50 ml of absolute toluene was added 15 ml of propionic anhydride. After refluxing for 4 hours, toluene and excess propionic anhydride were evaporated under reduced pressure to afford a residue. To the solution of the residue in 50 ml of toluene was added 0.6 g of dimethylaminopyridine and refluxed for 20 hours. The reaction mixture was evaporated under reduced pressure. The residue was purified by silica-gel column chromatography to afford 4.96 g of the title compound as yellow solid.

Provenance & Evidence