HCID 70272683, compound → HCID 70274025, compound

Participants

Reaction Steps

A mixture of Example 14 (475 mg, 0.723 mmol) and 10% Pd/C (50 mg) in ethanol (30 mL) was stirred under an atmosphere of hydrogen for 2 h after which time a further batch of catalyst (50 mg) was added. After 6 h the solids were removed by filtration through celite to afford the crude titled product as a white foam (380 mg). TLC (3% methanol in methylene chloride) Rf =0.23. 1H NMR (300 MHz, CDCl3) d 0.97 (2×d, J=7.0 Hz, 6H), 2.62 (dd, J=13.0, 6.2 Hz, 1H), 2.97 (dd, J=13.0, 4.1 Hz, 1H), 3.64 (s, 3H), 3.70 (d, J=16.6.0 Hz, 1H), 4.19 (d, J=16.6.0 Hz, 1H) 4.90 (m, 2H), 6.38 (d, J=9.0 Hz, 1H), 6.6-7.6 (m, 20H). C34H36N4O5 requires m/z 580.6838; found 580.6852.

Provenance & Evidence