Nitric Acid → HCID 18769497, compound

HRID 1870673Notes

Reaction equation

HRID 1870673 reaction equation
C([NH:4][C:5]1[N:9]([CH3:10])[N:8]=[C:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:6]=1)(=O)C.[N+:15]([O-])([OH:17])=[O:16]>S(=O)(=O)(O)O>[NH2:4][C:5]1[N:9]([CH3:10])[N:8]=[C:7]([C:11]([CH3:12])([CH3:13])[CH3:14])[C:6]=1[N+:15]([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 6489269HCID 6489269, compound

Product 1

HCID 18769497HCID 18769497, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To 30 cm3 of concentrated sulphuric acid were added 8.5 g (0.044 mol) of 5-acetamido-1-methyl-3-tert-butylpyrazole, at 5° C. with vigorous stirring, followed by 2.5 cm3 (0.066 mol) of fuming nitric acid. After stirring for 2 hours, the reaction mixture was poured onto 100 g of ice and stirred for 30 minutes. The solid obtained was filtered off on a sinter funnel, washed with 20 cm3 of water and then dried under vacuum at 40° C. 8.5 g of the expected product were obtained in the form of a yellow solid, the melting point of which was 124° C.

Workup

  1. customat 5° C.
  2. stirringstirred for 30 minutes
  3. customThe solid obtained
  4. filtrationwas filtered off on a sinter funnel
  5. washwashed with 20 cm3 of water
  6. customdried under vacuum at 40° C

Sources & evidence

ORD record
ord-477fe03347f446d38cb8c4963ecc5d1b
Source dataset
uspto-grants-2000_08
Patent number
US06099592

Reaction notes

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