Ethyl Acetoacetate → HCID 178429174, compound

Participants

Reaction Steps

50 g of 4-nitro-2H-pyrazol-3-ylamine hydrochloride (prepared according to H. Dorn and H. Dilcher, Liebigs Ann. Chem., 707, 141, 1967) and 60 g of ethyl acetoacetate in 160 cc of acetic acid were introduced into a 500 cc three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer and a condenser. The reaction medium was refluxed for 12 h. The precipitate formed was filtered off at about 90° C. It was rinsed with diisopropyl ether and dried under vacuum over phosphorus pentoxide. 50 g of 3-nitro-5-methylpyrazolo[1,5-a]pyrimidin-7-ol were obtained in the form of yellow crystals. (Yield=84.5%; melting point=290° C. with decomposition).

Provenance & Evidence