Ammonia → HCID 9948502, compound

Participants

Reaction Conditions

Reaction Steps

The product of step (c) above (2.0 g, 6 mmol) was dissolved in an excess of a 7M solution of anhydrous ammonia in methanol and heated at 50° C. for 6 h. After evaporation of the solvent the residue was purified by flash chromatography on silica gel using dichloromethane/methanol (98:2) as eluent to give the title compound as a solid (1.8 g), m.p. 114-116° C. Mass spectrum (+ve CI)m /z 308 (M+ +H). Found: C, 58.63; H, 5.84; N, 13.67. Required for C15H18FN3O3 : C, 58.62; H, 5.90; N, 13.67%.

Provenance & Evidence