3,5-Dimethylisoxazole-4-sulfonamide → N-(3,5-Dimethylisoxazol-4-ylsulphonyl)-6-[N-(5-chloro-2-(cyclohexen-3-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

HRID 1870747Notes

Reaction equation

HRID 1870747 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH:24]=[CH:23]2)=[C:6]([CH:20]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]([OH:19])=O)=[CH:13][CH:12]=1)[CH2:9][CH3:10].[CH3:28][C:29]1[C:33]([S:34]([NH2:37])(=[O:36])=[O:35])=[C:32]([CH3:38])[O:31][N:30]=1>>[CH3:28][C:29]1[C:33]([S:34]([NH:37][C:17]([C:14]2[N:15]=[N:16][C:11]([N:8]([CH2:7][C:6]3[CH:20]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:21][CH:22]3[CH2:27][CH2:26][CH2:25][CH:24]=[CH:23]3)[CH2:9][CH3:10])=[CH:12][CH:13]=2)=[O:19])(=[O:36])=[O:35])=[C:32]([CH3:38])[O:31][N:30]=1

Participants

3

Reactant 2

HCID 49623033,5-Dimethylisoxazole-4-sulfonamideHCID 186932356-[N-(5-Chloro-2-(cyclohexen-3-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid

Product 1

HCID 18693269N-(3,5-Dimethylisoxazol-4-ylsulphonyl)-6-[N-(5-chloro-2-(cyclohexen-3-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

Procedure

The title compound was prepared from 6-[N-(5-chloro-2-(cyclohexen-3-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid (example 23) and 3,5-dimethylisoxazol-4-ylsulphonamide using a similar method to that of example 11 (Yield 22%).

Sources & evidence

ORD record
ord-5797b1bf282e40e2b84ca5438309d817
Source dataset
uspto-grants-2000_08
Patent number
US06100258

Reaction notes

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