Dimethylamine → HCID 54210895, compound

HRID 1870828Notes

Reaction equation

HRID 1870828 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9](=[N:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])SC)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20][NH:21][CH3:22]>>[C:1]([O:5][C:6]([NH:8][C:9](=[N:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[N:21]([CH3:22])[CH3:20])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 5466031,3-DI-Boc-2-methylisothiourea

Product 1

HCID 54210895HCID 54210895, compound

Procedure

1,3-Di-(tert-butoxycarbonyl)-2-methyl-isothiourea (Japanese Patent Unexamined Publication No. 2-3661) (3.00 g) was dissolved in a 50% aqueous dimethylamine solution (40 ml) and the resulting solution was stirred at room temperature for 18 hours. The solvent was distilled off under reduced pressure and the residue was purified by a silica gel column chromatography to obtain the desired compound (2.58 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-142bd12c8c3d46dcbb193a196dc1a804
Source dataset
uspto-grants-2000_08
Patent number
US06100260

Reaction notes

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