Sulfuric Acid → HCID 54420690, compound

Participants

Reaction Steps

A mixture of biphenyl-4-yl-oxo-acetic acid methyl ester (A. T. Jeffries, et al., J. Org. Chem., 46, 2885(1981)) (10 g), triethyl orthoformate (43 ml), methanol (60 ml) and conc. sulfuric acid (3 ml) was heated under reflux for 8.5 hours under a nitrogen atmosphere. The resulting mixture was poured into a saturated aqueous sodium bicarbonate solution and the resulting mixture was subjected to extraction with diethyl ether. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried over sodium sulfate and thereafter concentrated under reduced pressure, to obtain the desired compound (10.5 g).

Provenance & Evidence