HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Bromochlorobenzene → 3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Bromochlorobenzene | HCID 7806 | — |
| Reactant | Npc164516 | HCID 79038 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol | HCID 434488 | — |
Reaction Steps
The title compound was prepared from 4-bromochlorobenzene (15.4 g, 81 mmol), n-butyllithium in hexanes (31 mL 2.5 M; 78 mmol) and 8-methyl-8-azabicyclo[3.2.1]-octan-3-one (5 g, 36 mmol). Yield 5.7 g (63%) as a white solid, m.p. 186.3-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100275 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-63b26ae4dca64bc48bf0ca3ebfb11381 |
| Source note | uspto-grants-2000_08 |