HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromotoluene → HCID 434533, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromotoluene | HCID 7805 | — |
| Reactant | Npc164516 | HCID 79038 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 434533 | HCID 434533 | — |
Reaction Steps
The title compound was prepared from 4-bromotoluene (13.9 g, 81.4 mmol), n-butyllithium in hexanes (31.2 mL, 2.5 M; 78 mmol) and 8-methyl-8-azabicyclo[3.2.1]-octan-3-one (5 g, 35.9 mmol) in anhydrous tetrahydrofuran (40 mL). Yield 3.5 g (42%) as a white solid, m.p. 247-249° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100275 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-baf512550d8b47efaad7b28a26b10257 |
| Source note | uspto-grants-2000_08 |