HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoanisole → 3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | Npc164516 | HCID 79038 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol | HCID 434459 | — |
Reaction Steps
The title compound was prepared from 4-bromoanisole (15.1 g, 80.5 mmol), n-butyllithium in hexanes (31.2 mL, 2.5 M; 77.9 mmol) and 8-methyl-8-azabicyclo-[3.2.1]octan-3-one (5 g, 36 mmol) in anhydrous tetrahydrofuran (40 mL). Yield 2.1 g (24%), m.p. 161.8-162.3° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100275 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-6b6ccf569ead46aa98f909101f242331 |
| Source note | uspto-grants-2000_08 |